Spyndle is a computational platform that resolves the five-fold pore of any AAV serotype or mutant down to the atom, turning structure, not guesswork, into the decision to build, screen, or scale.
Every serotype and mutant ships as a panel of interactive simulations, pore geometry, gating dynamics, and lining chemistry, so researchers can characterize a candidate and understand exactly what they are looking at. When an initial profile justifies deeper resolution, teams commission full molecular-dynamics runs, executed on demand by a fleet of compute agents.
The same pipeline runs for any serotype or point mutant: slice the pore, minimize and profile it, then watch it move.
Structure-derived five-fold axis and constriction ring, extracted directly from the deposited capsid geometry not a literature-average cylinder.
Throat radius, roughness, and lining-residue chemistry measured off real heavy-atom surfaces, before and after any mutation.
Short restrained dynamics reveal gate flexibility and opening frequency that a single static structure can't show and sometimes reverses it.
Early access is limited to a small group of manufacturing and R&D partners.